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Article

DNA replication origin function is promoted by H3K4 di-methylation in Saccharomyces cerevisiae.

Genetics - 1 Oct 2012

Rizzardi Lindsay F, Dorn Elizabeth S, Strahl Brian D, Cook Jeanette Gowen

Abstract excerpt

DNA replication is a highly regulated process that is initiated from replication origins, but the elements of chromatin structure that contribute to origin activity have not been fully elucidated. To identify histone post-translational modifications important for DNA replication, we initiated a genetic screen to identify interactions between genes encoding chromatin-modifying enzymes and those encoding proteins...

Topics

Cell Cycle Proteins
Chromatin
DNA Methylation
DNA Replication
Histone-Lysine N-Methyltransferase
Mutation
Protein Processing, Post-Translational
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Ubiquitination

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Identifiers

PMID: 22851644
DOI: 10.1534/genetics.112.142349
PMCID: PMC3454870

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-22851644-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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