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Article

Association of hippocampal volume polygenic predictor score with baseline and change in brain volumes and cognition among cognitively healthy older adults.

Neurobiology of aging - 1 Oct 2020

Armstrong Nicole M, Dumitrescu Logan, Huang Chiung-Wei, An Yang, Tanaka Toshiko, Hernandez Dena, Doshi Jimit, Erus Guray, Davatzikos Christos, Ferrucci Luigi, Resnick Susan M, Hohman Timothy J

Abstract excerpt

A high hippocampal volume polygenic predictor score (HV-PPS), computed based on GWAS summary statistics (n = 33,536), could be protective against declines in brain volume and cognition in older adults. Linear mixed-effects models with random intercepts and slopes were used to estimate associations of HV-PPS with baseline and annual rate of change in both brain volumes (n = 508) and cognitive performance (n =...

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Identifiers

PMID: 32593031
DOI: 10.1016/j.neurobiolaging.2020.05.007
PMCID: PMC8893954

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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