Article
Genetic, psychosocial and clinical factors associated with hippocampal volume in the general population.
Translational psychiatry - 14 Oct 2014
Janowitz D, Schwahn C, Borchardt U, Wittfeld K, Schulz A, Barnow S, Biffar R, Hoffmann W, Habes M, Homuth G, Nauck M, Hegenscheid K, Lotze M, Völzke H, Freyberger H J, Debette S, Grabe H J
Abstract excerpt
The hippocampus--crucial for memory formation, recall and mood regulation--is involved in the pathophysiology of dementia and depressive disorders. Recent genome-wide association studies (GWAS) have identified five genetic loci associated with hippocampal volume (HV). Previous studies have described psychosocial and clinical factors (for example, smoking, type 2 diabetes and hypertension) to have an impact on HV....
Topics
- Adult
- Age Factors
- Aged
- Blood Pressure
- Body Height
- Comorbidity
- Depressive Disorder
- Educational Status
- Female
- Genome-Wide Association Study