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Article

JAM-A functions as a female microglial tumor suppressor in glioblastoma

19 Jun 2020

Abstract excerpt

BACKGROUND: Glioblastoma (GBM) is the most aggressive primary brain tumor and has a dismal prognosis. Previously, we identified that junctional adhesion molecule A (JAM-A), a cell adhesion molecule, is highly elevated in human GBM cancer stem cells and predicts poor patient prognosis. While JAM-A is also highly expressed in other cells in the tumor microenvironment, specifically microglia and macrophages, how...

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PMID: 32592484
DOI: 10.1093/neuonc/noaa148

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