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Circadian Regulator CLOCK Drives Immunosuppression in Glioblastoma

12 Apr 2022

Abstract excerpt

The symbiotic interactions between cancer stem cells and the tumor microenvironment (TME) are critical for tumor progression. However, the molecular mechanism underlying this symbiosis in glioblastoma (GBM) remains enigmatic. Here, we show that circadian locomotor output cycles kaput (CLOCK) and its heterodimeric partner brain and muscle ARNT-like 1 (BMAL1) in glioma stem cells (GSC) drive immunosuppression in...

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PMID: 35413115
DOI: 10.1158/2326-6066.cir-21-0559

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