Article

TREM2 promotes glioma progression and angiogenesis mediated by microglia/brain macrophages

2023-05-19

Abstract excerpt

TREM2, a myeloid cell-specific signaling molecule, controls essential functions of microglia and impacts on the pathogenesis of Alzheimer’s disease and other neurodegenerative disorders. TREM2 is also highly expressed in tumor-associated macrophages and plays detrimental roles in an experimental mouse sarcoma model. Here we studied whether TREM2 influences glioma progression. We found a sex- dependent effect of TR...

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Literature Corpus work: 1e20e5db-782c-59ea-be23-c7dd6a6cd0ed
DOI: 10.1101/2023.05.18.540621

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