Article

Myeloid-derived suppressor cell subsets drive glioblastoma growth in a sex-specific manner

2020-02-20

Abstract excerpt

Myeloid-derived suppressor cells (MDSCs) that block anti-tumor immunity are elevated in glioblastoma (GBM) patients. However, the distinct contribution of monocytic (mMDSC) versus granulocytic (gMDSC) subsets has yet to be determined. We observed that mMDSCs were enriched in the male tumor microenvironment, while gMDSCs were elevated in the circulation of female GBM models. Depletion of peripheral gMDSCs extended...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 72de2479-2011-55d4-aeaf-93014d142793
DOI: 10.1101/2020.02.19.954552

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Myeloid-derived suppressor cell subsets drive glioblastoma growth in a sex-specific mannerDOI 10.1101/2020.02.19.954552Read

Distinct Myeloid Derived Suppressor Cell Populations Promote Tumor Aggression in GlioblastomaSemantic proximity Read

Distinct myeloid-derived suppressor cell populations in human glioblastoma.Semantic proximity Read

Expanded tumor-associated polymorphonuclear Myeloid-derived suppressor cells in Waldenstrom macroglobulinemia display immune suppressive activitySemantic proximity Read

Sex-specific T cell exhaustion drives differential immune responses in glioblastomaSemantic proximity Read

Enrichment of a neutrophil-like monocyte transcriptional state in glioblastoma myeloid suppressor cellsSemantic proximity Read

Glioma-derived M-CSF and IL-34 license M-MDSCs to suppress CD8 <sup>+</sup> T cells in a NOS-dependent mannerSemantic proximity Read

Sex-Biased T-cell Exhaustion Drives Differential Immune Responses in GlioblastomaSemantic proximity Read

Distinct cell adhesion signature defines glioblastoma myeloid-derived suppressor cell subsetsSemantic proximity Read

Functional Characterization of Brain Tumor-Initiating Cells and Establishment of GBM Preclinical Models that Incorporate Heterogeneity, Therapy, and Sex DifferencesSemantic proximity Read

Myeloid-specific KDM6B inhibition sensitizes glioblastoma to PD1 blockade.Semantic proximity Read

Myeloid-specific KDM6B inhibition sensitizes Glioblastoma to PD1 blockadeSemantic proximity Read

Sex-specific molecular differences in glioblastoma: assessing the clinical significance of genetic variantsSemantic proximity Read