Article
The mutREAD method detects mutational signatures from low quantities of cancer DNA.
Nature communications - 23 Jun 2020
Perner Juliane, Abbas Sujath, Nowicki-Osuch Karol, Devonshire Ginny, Eldridge Matthew D, Tavaré Simon, Fitzgerald Rebecca C
Abstract excerpt
Mutational processes acting on cancer genomes can be traced by investigating mutational signatures. Because high sequencing costs limit current studies to small numbers of good-quality samples, we propose a robust, cost- and time-effective method, called mutREAD, to detect mutational signatures from small quantities of DNA, including degraded samples. We show that mutREAD recapitulates mutational signatures...
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