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Article

DeconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution.

Genome biology - 22 Feb 2016

Rosenthal Rachel, McGranahan Nicholas, Herrero Javier, Taylor Barry S, Swanton Charles

Abstract excerpt

BACKGROUND: Analysis of somatic mutations provides insight into the mutational processes that have shaped the cancer genome, but such analysis currently requires large cohorts. We develop deconstructSigs, which allows the identification of mutational signatures within a single tumor sample. RESULTS: Application of deconstructSigs identifies samples with DNA repair deficiencies and reveals distinct and dynamic...

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Identifiers

PMID: 26899170
DOI: 10.1186/s13059-016-0893-4
PMCID: PMC4762164

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