A comprehensive catalogue of somatic mutations from a human cancer genome.

doi:10.1038/nature08658

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Article

A comprehensive catalogue of somatic mutations from a human cancer genome.

Nature - 14 Jan 2010

Pleasance Erin D, Cheetham R Keira, Stephens Philip J, McBride David J, Humphray Sean J, Greenman Chris D, Varela Ignacio, Lin Meng-Lay, Ordóñez Gonzalo R, Bignell Graham R, Ye Kai, Alipaz Julie, Bauer Markus J, Beare David, Butler Adam, Carter Richard J, Chen Lina, Cox Anthony J, Edkins Sarah, Kokko-Gonzales Paula I, Gormley Niall A, Grocock Russell J, Haudenschild Christian D, Hims Matthew M, James Terena, Jia Mingming, Kingsbury Zoya, Leroy Catherine, Marshall John, Menzies Andrew, Mudie Laura J, Ning Zemin, Royce Tom, Schulz-Trieglaff Ole B, Spiridou Anastassia, Stebbings Lucy A, Szajkowski Lukasz, Teague Jon, Williamson David, Chin Lynda, Ross Mark T, Campbell Peter J, Bentley David R, Futreal P Andrew, Stratton Michael R

Abstract excerpt

All cancers carry somatic mutations. A subset of these somatic alterations, termed driver mutations, confer selective growth advantage and are implicated in cancer development, whereas the remainder are passengers. Here we have sequenced the genomes of a malignant melanoma and a lymphoblastoid cell line from the same person, providing the first comprehensive catalogue of somatic mutations from an individual...

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Identifiers

PMID: 20016485
DOI: 10.1038/nature08658
PMCID: PMC3145108

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