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Comparing the predictors of mutability among healthy human tissues inferred from mutations in single-cell genome data.

Genetics - 17 Mar 2025

Oman Madeleine, Ness Rob W

Abstract excerpt

Studying mutation in healthy somatic tissues is the key for understanding the genesis of cancer and other genetic diseases. Mutation rate varies from site to site in the human genome by up to 100-fold and is influenced by numerous epigenetic and genetic factors including GC content, trinucleotide sequence context, and DNAse accessibility. These factors influence mutation at both local and regional scales and are...

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PMID: 39950507
DOI: 10.1093/genetics/iyae215

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GC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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