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Article

Significance and limitations of the use of next-generation sequencing technologies for detecting mutational signatures.

DNA repair - 1 Nov 2021

Abbasi Ammal, Alexandrov Ludmil B

Abstract excerpt

Next generation sequencing technologies (NGS) have been critical in characterizing the genomic landscape and untangling the genetic heterogeneity of human cancer. Since its advent, NGS has played a pivotal role in identifying the patterns of somatic mutations imprinted on cancer genomes and in deciphering the signatures of the mutational processes that have generated these patterns. Mutational signatures serve as...

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PMID: 34411908
DOI: 10.1016/j.dnarep.2021.103200
PMCID: PMC9478565

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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