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MutSignatures: an R package for extraction and analysis of cancer mutational signatures.

Scientific reports - 26 Oct 2020

Fantini Damiano, Vidimar Vania, Yu Yanni, Condello Salvatore, Meeks Joshua J

Abstract excerpt

Cancer cells accumulate somatic mutations as result of DNA damage, inaccurate repair and other mechanisms. Different genetic instability processes result in characteristic non-random patterns of DNA mutations, also known as mutational signatures. We developed mutSignatures, an integrated R-based computational framework aimed at deciphering DNA mutational signatures. Our software provides advanced functions for...

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Identifiers

PMID: 33106540
DOI: 10.1038/s41598-020-75062-0
PMCID: PMC7589488

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