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Mutational Signatures in Cancer: Laboratory Considerations and Emerging Applications.

The Journal of molecular diagnostics : JMD - 1 Nov 2023

Dong Fei, Davies Kurtis D

Abstract excerpt

Patterns of somatic mutations have emerged from the broad sequencing of human cancer genomes. These mutational signatures reflect mechanisms of mutagenesis and DNA repair defects and represent an emerging class of cancer biomarkers. The appropriate interpretation of mutational signatures from sequencing assays holds implications in the reporting of molecular diagnostic results for patients with cancer. This brief...

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Identifiers

PMID: 37633594
DOI: 10.1016/j.jmoldx.2023.08.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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