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Article

Genetic variants in NECTIN4 encoding an adhesion molecule are associated with continued opioid use.

PloS one - 1 Jan 2020

Fang Chiu-Ping, Liu Tung-Hsia, Chung Ren-Hua, Tsou Hsiao-Hui, Kuo Hsiang-Wei, Wang Sheng-Chang, Liu Chia-Chen, Liu Shu Chih, Chen Andrew C H, Liu Yu-Li

Abstract excerpt

Methadone is a synthetic opioid used as maintenance treatment for patients addicted to heroin. Skin irritation is one of the adverse events caused by opioid use. 344 methadone maintenance treatment (MMT) patients were recruited with records and measurements on methadone dose, plasma methadone concentrations, and treatment emergent symptom scales (TESS). 15 patients reported with skin irritation. Five SNPs located...

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Share to Analgesics, Opioid
Share to Cell Adhesion Molecules

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Heroin Dependence

Share to Methadone

Share to Opioid-Related Disorders

Source

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Identifiers

PMID: 32555608
DOI: 10.1371/journal.pone.0234549
PMCID: PMC7302666

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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