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Article

β-Arrestin 2 (ARRB2) Polymorphism is Associated With Adverse Consequences of Chronic Heroin Use.

The American journal on addictions - 1 Jul 2021

Karavidha Klevis K, Burmeister Margit, Greenwald Mark K

Abstract excerpt

BACKGROUND AND OBJECTIVES: β-arrestin 2 is an intracellular protein recruited during the activation of G-protein-coupled receptors. In preclinical studies, β-arrestin 2 has been implicated in µ-opioid receptor desensitization and internalization and the development of opioid tolerance and dependence. The present study investigated relationships between variants in the gene encoding β-arrestin 2 (ARRB2) and...

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Identifiers

PMID: 33783060
DOI: 10.1111/ajad.13150
PMCID: PMC8243774

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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