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Article

KCNH2 polymorphism and methadone dosage interact to enhance QT duration.

Drug and alcohol dependence - 1 Aug 2014

Hajj Aline, Ksouda Kamilia, Peoc'h Katell, Curis Emmanuel, Messali Anne, Deveaux Laurence Labat, Bloch Vanessa, Prince Nathalie, Mouly Stéphane, Scherrmann Jean-Michel, Lépine Jean-Pierre, Laplanche Jean-Louis, Drici Milou-Daniel, Vorspan Florence

Abstract excerpt

BACKGROUND: Many drugs increase the duration of the QT interval of patients, potentially leading to harmful effects such as polymorphic ventricular arrhythmias. Most of these drugs do so by inhibiting the rapid component IKr of the delayed rectifier potassium current IK. Methadone is the most prescribed heroin maintenance treatment and is known to inhibit the cardiac potassium channel hERG, which recapitulates...

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Source

Identifiers

PMID: 24875677
DOI: 10.1016/j.drugalcdep.2014.04.027

Genes

KCNH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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