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Article

Association of the D-amino acid oxidase gene with methadone dose in heroin dependent patients under methadone maintenance treatment.

Journal of human genetics - 1 May 2022

Liu Tung-Hsia, Tsou Hsiao-Hui, Chung Ren-Hua, Liu Shu Chih, Wang Sheng-Chang, Kuo Hsiang-Wei, Fang Chiu-Ping, Chen Andrew C H, Liu Yu-Li

Abstract excerpt

Methadone is a synthetic opioid used for the maintenance treatment (MMT) of heroin dependence. It primarily binds to the μ-opioid receptor (MOR; with its gene, namely OPRM1). Methadone is also an N-methyl-D-aspartate (NMDA) receptor antagonist. The role of NMDA receptor in the regulatory mechanisms of methadone dosage in heroin dependent patients is so far not clear. D-amino acid oxidase (DAO) is an important...

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PMID: 34983973
DOI: 10.1038/s10038-021-01008-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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