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The genomic and epigenomic evolutionary history of papillary renal cell carcinomas

18 Jun 2020

Abstract excerpt

Intratumor heterogeneity (ITH) and tumor evolution have been well described for clear cell renal cell carcinomas (ccRCC), but they are less studied for other kidney cancer subtypes. Here we investigate ITH and clonal evolution of papillary renal cell carcinoma (pRCC) and rarer kidney cancer subtypes, integrating whole-genome sequencing and DNA methylation data. In 29 tumors, up to 10 samples from the center to...

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PMID: 32555180
DOI: 10.1038/s41467-020-16546-5

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