Selection of metastasis competent subclones in the tumour interior.

doi:10.1038/s41559-021-01456-6

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Article

Selection of metastasis competent subclones in the tumour interior.

Nature ecology & evolution - 1 Jul 2021

Zhao Yue, Fu Xiao, Lopez Jose I, Rowan Andrew, Au Lewis, Fendler Annika, Hazell Steve, Xu Hang, Horswell Stuart, Shepherd Scott T C, Spain Lavinia, Byrne Fiona, Stamp Gordon, O'Brien Tim, Nicol David, Augustine Marcellus, Chandra Ashish, Rudman Sarah, Toncheva Antonia, Pickering Lisa, Sahai Erik, Larkin James, Bates Paul A, Swanton Charles, Turajlic Samra, Litchfield Kevin

Abstract excerpt

The genetic evolutionary features of solid tumour growth are becoming increasingly well described, but the spatial and physical nature of subclonal growth remains unclear. Here, we utilize 102 macroscopic whole-tumour images from clear cell renal cell carcinoma patients, with matched genetic and phenotypic data from 756 biopsies. Utilizing a digital image processing pipeline, a renal pathologist marked the...

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Identifiers

PMID: 34002049
DOI: 10.1038/s41559-021-01456-6
PMCID: PMC7611703

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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