Article
Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing.
Nature genetics - 1 Mar 2014
Gerlinger Marco, Horswell Stuart, Larkin James, Rowan Andrew J, Salm Max P, Varela Ignacio, Fisher Rosalie, McGranahan Nicholas, Matthews Nicholas, Santos Claudio R, Martinez Pierre, Phillimore Benjamin, Begum Sharmin, Rabinowitz Adam, Spencer-Dene Bradley, Gulati Sakshi, Bates Paul A, Stamp Gordon, Pickering Lisa, Gore Martin, Nicol David L, Hazell Steven, Futreal P Andrew, Stewart Aengus, Swanton Charles
Abstract excerpt
Clear cell renal carcinomas (ccRCCs) can display intratumor heterogeneity (ITH). We applied multiregion exome sequencing (M-seq) to resolve the genetic architecture and evolutionary histories of ten ccRCCs. Ultra-deep sequencing identified ITH in all cases. We found that 73-75% of identified ccRCC driver aberrations were subclonal, confounding estimates of driver mutation prevalence. ITH increased with the number...
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