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Article

Parallel evolution of tumour subclones mimics diversity between tumours.

The Journal of pathology - 1 Aug 2013

Martinez Pierre, Birkbak Nicolai Juul, Gerlinger Marco, McGranahan Nicholas, Burrell Rebecca A, Rowan Andrew J, Joshi Tejal, Fisher Rosalie, Larkin James, Szallasi Zoltan, Swanton Charles

Abstract excerpt

Intratumour heterogeneity (ITH) may foster tumour adaptation and compromise the efficacy of personalized medicine approaches. The scale of heterogeneity within a tumour (intratumour heterogeneity) relative to genetic differences between tumours (intertumour heterogeneity) is unknown. To address t...

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Identifiers

PMID: 23716380
DOI: 10.1002/path.4214

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23716380-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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