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Clonal architectures predict clinical outcome in clear cell renal cell carcinoma

18 Mar 2019

Abstract excerpt

Abstract The genetic landscape of clear cell renal cell carcinoma (ccRCC) had been investigated extensively but its evolution patterns remained unclear. Here we analyze the clonal architectures of 473 patients from three different populations. We find that the mutational signatures vary substantially across different populations and evolution stages. The evolution patterns of ccRCC have great inter-patient...

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PMID: 30886153
DOI: 10.1038/s41467-019-09241-7

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