Article
Recurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution.
Nature communications - 19 Mar 2015
Kovac Michal, Navas Carolina, Horswell Stuart, Salm Max, Bardella Chiara, Rowan Andrew, Stares Mark, Castro-Giner Francesc, Fisher Rosalie, de Bruin Elza C, Kovacova Monika, Gorman Maggie, Makino Seiko, Williams Jennet, Jaeger Emma, Jones Angela, Howarth Kimberley, Larkin James, Pickering Lisa, Gore Martin, Nicol David L, Hazell Steven, Stamp Gordon, O'Brien Tim, Challacombe Ben, Matthews Nik, Phillimore Benjamin, Begum Sharmin, Rabinowitz Adam, Varela Ignacio, Chandra Ashish, Horsfield Catherine, Polson Alexander, Tran Maxine, Bhatt Rupesh, Terracciano Luigi, Eppenberger-Castori Serenella, Protheroe Andrew, Maher Eamonn, El Bahrawy Mona, Fleming Stewart, Ratcliffe Peter, Heinimann Karl, Swanton Charles, Tomlinson Ian
Abstract excerpt
Papillary renal cell carcinoma (pRCC) is an important subtype of kidney cancer with a problematic pathological classification and highly variable clinical behaviour. Here we sequence the genomes or exomes of 31 pRCCs, and in four tumours, multi-region sequencing is undertaken. We identify BAP1, SETD2, ARID2 and Nrf2 pathway genes (KEAP1, NHE2L2 and CUL3) as probable drivers, together with at least eight other...
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