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Article

How should clinicians address intratumour heterogeneity in clear cell renal cell carcinoma?

Current opinion in urology - 1 Sept 2015

Soultati Aspasia, Stares Mark, Swanton Charles, Larkin James, Turajlic Samra

Abstract excerpt

PURPOSE OF REVIEW: Despite the availability of multiple targeted therapies, the 5-year survival rate of patients with metastatic clear cell renal cell carcinoma (ccRCC) rarely exceeds 10%. Recent insights into the mutational landscape and evolutionary dynamics of ccRCC have offered up a plausible explanation for these outcomes. The purpose of this review is to link the research findings to potential changes in...

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Identifiers

PMID: 26125509
DOI: 10.1097/MOU.0000000000000204

Genes

BAP1
PTEN
SETD2
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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