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Multilayered molecular profiling supported the monoclonal origin of metastatic renal cell carcinoma

6 Dec 2013

Abstract excerpt

Primary renal cell carcinomas (pRCCs) have a high degree of intratumoral heterogeneity and are composed of multiple distinct subclones. However, it remains largely unknown that whether metastatic renal cell carcinomas (mRCCs) also have startling intratumoral heterogeneity or whether development of mRCCs is due to early dissemination or late diagnosis. To decipher the evolution of mRCC, we analyzed the...

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PMID: 24310851
DOI: 10.1002/ijc.28654

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