Analysis of Biomarkers of DNA Damage and Mutagenicity in Mice Exposed to Acrylonitrile.

doi:10.1021/acs.chemrestox.0c00154

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Article

Analysis of Biomarkers of DNA Damage and Mutagenicity in Mice Exposed to Acrylonitrile.

Chemical research in toxicology - 20 Jul 2020

Walker Vernon E, Walker Dale M, Ghanayem Burhan I, Douglas George R

Abstract excerpt

Acrylonitrile (ACN), which is a widely used industrial chemical, induces cancers in the mouse via unresolved mechanisms. For this report, complementary and previously described methods were used to assess in vivo genotoxicity and/or mutagenicity of ACN in several mouse models, including (i) female mice devoid of cytochrome P450 2E1 (CYP2E1), which yields the epoxide intermediate cyanoethylene oxide (CEO), (ii)...

Topics

Acrylonitrile
Administration, Oral
Animals
Biomarkers
Carcinogens
Cytochrome P-450 CYP2E1
DNA Damage
Disease Models, Animal
Dose-Response Relationship, Drug
Female
Hypoxanthine Phosphoribosyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mice

Mice, Inbred C57BL

Mice, Knockout

Mice, Transgenic

Mutagenicity Tests

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 32529832
DOI: 10.1021/acs.chemrestox.0c00154
PMCID: PMC7477827

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-32529832-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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