Article
Combined assessment of transgenic rodent gene mutation and micronuclei formation by benzo[a]pyrene, N-ethyl-N-nitrosourea, 2,4-diaminotoluene and ethyl carbamate.
Mutation research. Genetic toxicology and environmental mutagenesis - 1 Jan 2026
Goepfert Alina, Heid Patrick, Brandl Denise, Kuhn Daniela, Moos Bärbel, Wilson Tais Meziara, Dammann Martina, Honarvar Naveed, Landsiedel Robert
Abstract excerpt
This study combined an in vivo Transgenic Rodent Gene Mutation Assay (TGRA) and Mammalian Erythrocyte Micronucleus Test (MNT) using male MutaMouse to assess the four positive control substances recommended by the OECD test guideline no. 488: benzo[a]pyrene (B[a]P), N-ethyl-N-nitrosourea (ENU), 2,4-diaminotoluene (2,4-DAT), and ethyl carbamate (EC). The studies followed the procedures described in the OECD...
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