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1,3-Butadiene: Biomarkers and application to risk assessment.

Chemico-biological interactions - 30 Jun 2011

Swenberg James A, Bordeerat Narisa K, Boysen Gunnar, Carro Sujey, Georgieva Nadia I, Nakamura Jun, Troutman John M, Upton Patricia B, Albertini Richard J, Vacek Pamela M, Walker Vernon E, Sram Radim J, Goggin Melissa, Tretyakova Natalia

Abstract excerpt

1,3-Butadiene (BD) is a known rodent and human carcinogen that is metabolized mainly by P450 2E1 to three epoxides, 1,2-epoxy-3-butene (EB), 1,2:3,4-diepoxybutane (DEB) and 1,2-epoxy-3,4-butanediol (EB-diol). The individual epoxides vary up to 200-fold in their mutagenic potency, with DEB being the most mutagenic metabolite. It is important to understand the internal formation of the individual epoxides to assign...

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Identifiers

PMID: 20974116
DOI: 10.1016/j.cbi.2010.10.010
PMCID: PMC3501005

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