Article
Acrylamide induces specific DNA adduct formation and gene mutations in a carcinogenic target site, the mouse lung.
Mutagenesis - 1 Mar 2015
Ishii Yuji, Matsushita Kohei, Kuroda Ken, Yokoo Yuh, Kijima Aki, Takasu Shinji, Kodama Yukio, Nishikawa Akiyoshi, Umemura Takashi
Abstract excerpt
Acrylamide (AA) is a contaminant in heated foods and is carcinogenic in multiple organs of rodents. There have been many reports regarding AA-induced DNA modification and genotoxicity. However, the data are insufficient to understand fully the relationship between the two events. A recent report demonstrated carcinogenicity in the mouse lung. The lung is advantageous for investigation of AA-induced genotoxicity...
Topics
- Acrylamide
- Animals
- Carcinogens
- DNA Adducts
- DNA Mutational Analysis
- Lung
- Male
- Mice
- Mutation