Article

Molecular Dosimetry of DNA Adducts in Mice Exposed to Ethylene Oxide

2026-03-27

Abstract excerpt

<h4>ABSTRACT</h4> Ethylene oxide (EtO) is a highly reactive industrial chemical and classified as a known human carcinogen with a putative mutagenic mode of action (MOA). Its genotoxic potential is primarily mediated through alkylation of DNA, resulting in the formation of the mutagenic adduct O 6 -(2-hydroxyethyl)-2’-deoxyguanosine (O 6 -HE-dG). The N7-(2-hydroxyethyl)guanine (N7-HE-G) adduct is formed in grea...

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Literature Corpus work: b7e0b8ad-7020-50c4-894d-d624ee72b982
DOI: 10.64898/2026.03.25.714191

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