Article
Assessing the genotoxicity of N-nitrosodiethylamine with three in vivo endpoints in male Big Blue® transgenic and wild-type C57BL/6N mice.
Environmental and molecular mutagenesis - 1 Jul 2024
Zhang Shaofei, Coffing Stephanie L, Gunther William C, Homiski Michael L, Spellman Richard A, Van Phu, Schuler Maik
Abstract excerpt
The detection of N-nitrosamines in drug products has raised global regulatory interest in recent years due to the carcinogenic potential of some nitrosamines in animals and a need to identify a testing strategy has emerged. Ideally, methods used would allow for the use of quantitative analysis of dose-response data from in vivo genotoxicity assays to determine a compound-specific acceptable intake for novel...
Topics
- Animals
- Male
- Diethylnitrosamine
- Mice, Transgenic
- Mice, Inbred C57BL
- Mutagenicity Tests
- Mice
- Dose-Response Relationship, Drug
- DNA Damage
- Liver
- Mutagens