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Histopathologic Analysis of Signet-ring Cell Carcinoma In Situ in Patients With Hereditary Diffuse Gastric Cancer.

The American journal of surgical pathology - 1 Sept 2020

Tsugeno Yuta, Nakano Kaoru, Nakajima Takeshi, Namikawa Ken, Takamatsu Manabu, Yamamoto Noriko, Fujisaki Junko, Nunobe Souya, Kitagawa Masanobu, Takeuchi Kengo, Kawachi Hiroshi

Abstract excerpt

Hereditary diffuse gastric cancer (HDGC) is a rare autosomal dominant syndrome associated with an increased risk of developing Laurén's diffuse-type gastric carcinoma and lobular breast carcinoma. Although signet-ring cell carcinoma (SRCC) in situ (SRCC-pTis) has been reported as a characteristic lesion in HDGC cases with CDH1 germline mutations (CDH1 pathogenic variant), and a precursor of conventional...

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PMID: 32520759
DOI: 10.1097/PAS.0000000000001511

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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