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Article

Spatial Analysis of Hereditary Diffuse Gastric Cancer Reveals Indolent Phenotype of Signet Ring Cell Precursors.

Molecular cancer research : MCR - 4 Aug 2025

Gallanis Amber F, Gamble Lauren A, Oguz Cihan, Samaranayake Sarah G, Kedei Noemi, Hernandez Maria O, Wong Madeline, Tillo Desiree, Green Benjamin L, McClelland Paul, Bowden Cassidy, Gullo Irene, Raffeld Mark, Xi Liqiang, Kelly Michael, Miettinen Markku, Quezado Martha, Kim Sun A, Blakely Andrew M, Lack Justin, Heller Theo, Hernandez Jonathan M, Davis Jeremy L

Abstract excerpt

Germline CDH1 loss-of-function mutations are causally linked to an increased lifetime risk of diffuse gastric cancer (DGC). Early, multifocal signet ring cell (SRC) lesions are ubiquitous among CDH1 variant carriers, yet only a subset of patients will develop advanced DGC. A multiomic analysis was performed to establish the molecular phenotype of early SRC lesions and how they differ from advanced DGC using 20...

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Identifiers

PMID: 40192595
DOI: 10.1158/1541-7786.MCR-24-1039
PMCID: PMC12324967

Genes

SRC
CDH1
TP53
AGR2
AQP5
ARID1A
CTNNA1
ERBB3
KRAS
MET
MYC
PRR4
REG1A
VIM

Provenance

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