Article
Hereditary diffuse gastric cancer in a Japanese family with a large deletion involving CDH1.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association - 1 Oct 2014
Yamada Masayoshi, Fukagawa Takeo, Nakajima Takeshi, Asada Kiyoshi, Sekine Shigeki, Yamashita Satoshi, Okochi-Takada Eriko, Taniguchi Hirokazu, Kushima Ryoji, Oda Ichiro, Saito Yutaka, Ushijima Toshikazu, Katai Hitoshi
Abstract excerpt
Hereditary diffuse gastric cancer (HDGC), characterized by susceptibility to gastric signet ring cell carcinomas (SRCCs) and caused by CDH1 germline mutations, is rare in the Japanese. We present here a Japanese family with HDGC identified by comparative genomic hybridization (CGH) analysis. A 55-year-old woman was treated with completion gastrectomy for multiple SRCCs, and pathological examination revealed...
Topics
- Adult
- Antigens, CD
- Asian People
- Cadherins
- Carcinoma, Signet Ring Cell
- Female
- Gastrectomy
- Genetic Predisposition to Disease
- Humans