Article
Recognition of and recent issues in hereditary diffuse gastric cancer.
Journal of gastroenterology - 1 Aug 2015
Sugimoto Shinya, Komatsu Hirokazu, Morohoshi Yuichi, Kanai Takanori
Abstract excerpt
In East Asian countries, gastric cancer incidence is high, but detection rates for germline CDH1 mutations that cause hereditary diffuse gastric cancers (HDGCs) are low. Consequently, screens and genetic testing for HDGC are often considered unimportant. Since the first germline truncating CDH1 mutations in Japanese patients were reported, some HDGC cases have been reported, and some of these involve large...
Topics
- Animals
- Antigens, CD
- Cadherins
- Disease Models, Animal
- Genetic Predisposition to Disease
- Genetic Testing
- Germ-Line Mutation
- Humans
- Japan
- Neoplastic Syndromes, Hereditary
- Stomach Neoplasms