Article
Case series of three patients with hereditary diffuse gastric cancer in a single family: Three case reports and review of literature.
World journal of gastroenterology - 14 Nov 2020
Hirakawa Masahiro, Takada Kohichi, Sato Masanori, Fujita Chisa, Hayasaka Naotaka, Nobuoka Takayuki, Sugita Shintaro, Ishikawa Aki, Mizukami Miyako, Ohnuma Hiroyuki, Murase Kazuyuki, Miyanishi Koji, Kobune Masayoshi, Takemasa Ichiro, Hasegawa Tadashi, Sakurai Akihiro, Kato Junji
Abstract excerpt
BACKGROUND: Hereditary diffuse gastric cancer (HDGC) is a familial cancer syndrome often associated with germline mutations in the CDH1 gene. However, the frequency of CDH1 mutations is low in patients with HDGC in East Asian countries. Herein, we report three cases of HDGC harboring a missense C...
Topics
- Adult
- Cadherins
- Carcinoma, Signet Ring Cell
- Asia, Eastern
- Female
- Genetic Predisposition to Disease
- Germ-Line Mutation
- Humans
- Male
- Middle Aged
- Stomach Neoplasms