Complete histopathologic examination of risk reduction gastrectomy specimens for CDH1 germline mutation: Is it warranted in routine clinical practice?

doi:10.1016/j.anndiagpath.2020.151473

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Article

Complete histopathologic examination of risk reduction gastrectomy specimens for CDH1 germline mutation: Is it warranted in routine clinical practice?

Annals of diagnostic pathology - 1 Apr 2020

Zhang Qingzhao, Yang Zhaohai, Karamchandani Dipti M

Abstract excerpt

AIMS: CDH1 germline mutation is associated with high penetrance of hereditary diffuse gastric cancer (HDGC). Due to the lack of endoscopically identifiable lesions, routine surveillance is ineffective in the early detection of gastric cancer, and risk-reduction gastrectomy is often recommended. Many academic pathology departments elect to submit the entire gastrectomy specimen for histological examination, which...

Topics

Adult
Antigens, CD
Cadherins
Carcinoma in Situ
Carcinoma, Signet Ring Cell
Female
Gastrectomy
Genetic Predisposition to Disease
Genetic Testing
Germ-Line Mutation
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Neoplasm Staging

Neoplastic Syndromes, Hereditary

Retrospective Studies

Risk Reduction Behavior

Stomach Neoplasms

Source

Open in PubMed

Identifiers

PMID: 31986421
DOI: 10.1016/j.anndiagpath.2020.151473

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-31986421-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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