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Article

The Changing Landscape of Hereditary Diffuse Gastric Cancer.

Journal of gastric cancer - 1 Jan 2026

Vaessen Conor, Redpath Kieran, Schulpen Emily, Guilford Parry

Abstract excerpt

Hereditary diffuse gastric cancer (HDGC) is a dominantly inherited cancer syndrome characterized by the early onset of diffuse gastric cancer (DGC) and lobular breast cancer. HDGC is predominantly caused by germline truncating mutations in CDH1, which encodes the cell-cell adhesion protein, E-cadherin. Less frequent predisposing mutations are observed in the CTNNA1 gene that encodes α-catenin. E-cadherin and...

Topics

Humans
Stomach Neoplasms
Cadherins
Antigens, CD
alpha Catenin
Genetic Predisposition to Disease
Germ-Line Mutation
Neoplastic Syndromes, Hereditary
Gastrectomy

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Open in PubMed Open full text

Identifiers

PMID: 41517846
DOI: 10.5230/jgc.2026.26.e5
PMCID: PMC12802062

Genes

CDH1
CTNNA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-41517846-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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