Article
Histopathological, Molecular, and Genetic Profile of Hereditary Diffuse Gastric Cancer: Current Knowledge and Challenges for the Future.
Advances in experimental medicine and biology - 1 Jan 2000
van der Post Rachel S, Gullo Irene, Oliveira Carla, Tang Laura H, Grabsch Heike I, O'Donovan Maria, Fitzgerald Rebecca C, van Krieken Han, Carneiro Fátima
Abstract excerpt
Familial clustering is seen in 10 % of gastric cancer cases and approximately 1-3 % of gastric cancer arises in the setting of hereditary diffuse gastric cancer (HDGC). In families with HDGC, gastric cancer presents at young age. HDGC is predominantly caused by germline mutations in CDH1 and in a minority by mutations in other genes, including CTNNA1. Early stage HDGC is characterized by a few, up to dozens of...
Topics
- Animals
- Biomarkers, Tumor
- Biomedical Research
- Forecasting
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic
- Genetic Predisposition to Disease
- Humans
- Mutation