Article
Two independent families with strongly suspected hereditary diffuse gastric cancer based on the probands' endoscopic findings.
Clinical journal of gastroenterology - 1 Oct 2020
Iwaizumi Moriya, Yamada Hidetaka, Fukue Misaki, Maruyama Yasuhiko, Sonoda Ayano, Sugimoto Mitsushige, Koda Kenji, Kushima Ryoji, Maekawa Masato, Sugimura Haruhiko
Abstract excerpt
Hereditary diffuse gastric cancer (HDGC) is the most famous of hereditary gastric cancer syndromes with an autosomal dominant inheritance pattern, and its diagnosis can be made by identifying a pathogenic germline variant in CDH1. We report two independent families that were strongly suspected of having HDGC based on endoscopic findings (multiple tiny, pale areas) obtained in the probands; the probands were...
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