Article
Whole-genome sequencing of glioblastoma reveals enrichment of non-coding constraint mutations in known and novel genes.
Genome biology - 9 Jun 2020
Sakthikumar Sharadha, Roy Ananya, Haseeb Lulu, Pettersson Mats E, Sundström Elisabeth, Marinescu Voichita D, Lindblad-Toh Kerstin, Forsberg-Nilsson Karin
Abstract excerpt
BACKGROUND: Glioblastoma (GBM) has one of the worst 5-year survival rates of all cancers. While genomic studies of the disease have been performed, alterations in the non-coding regulatory regions of GBM have largely remained unexplored. We apply whole-genome sequencing (WGS) to identify non-coding mutations, with regulatory potential in GBM, under the hypothesis that regions of evolutionary constraint are likely...
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