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Regulatory non-coding somatic mutations as drivers of neuroblastoma

23 Jan 2025

Abstract excerpt

BACKGROUND: Emerging evidence suggests that non-coding somatic single nucleotide variants (SNVs) in cis-regulatory elements (CREs) contribute to cancer by disrupting gene expression networks. However, the role of non-coding SNVs in cancer, particularly neuroblastoma, remains largely unclear. METHODS: SNVs effect on CREs activity was evaluated by luciferase assays. Motif analysis and ChIP-qPCR experiments were...

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PMID: 39843641
DOI: 10.1038/s41416-025-02939-0

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