Article
Using evolutionary constraint to define novel candidate driver genes in medulloblastoma.
Proceedings of the National Academy of Sciences of the United States of America - 15 Aug 2023
Roy Ananya, Sakthikumar Sharadha, Kozyrev Sergey V, Nordin Jessika, Pensch Raphaela, Mäkeläinen Suvi, Pettersson Mats, Karlsson Elinor K, Lindblad-Toh Kerstin, Forsberg-Nilsson Karin
Abstract excerpt
Current knowledge of cancer genomics remains biased against noncoding mutations. To systematically search for regulatory noncoding mutations, we assessed mutations in conserved positions in the genome under the assumption that these are more likely to be functional than mutations in positions with low conservation. To this end, we use whole-genome sequencing data from the International Cancer Genome Consortium...
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