Article
An integrated analysis of germline and somatic, genetic and epigenetic alterations at 9p21.3 in glioblastoma.
Cancer - 1 Jan 2012
Feng Junjie, Kim Seong-Tae, Liu Wennuan, Kim Jin Woo, Zhang Zheng, Zhu Yi, Berens Michael, Sun Jielin, Xu Jianfeng
Abstract excerpt
BACKGROUND: Glioblastoma multiforme (GBM) is the most prevalent and deadly brain tumor. A variety of germline and somatic, genetic and epigenetic alterations at 9p21.3, which encode CDKN2A/CDKN2B tumor suppressor genes, have been isolatedly reported to be associated with GBM risk and prognosis. METHODS: To obtain a comprehensive view of these events, we leveraged the wide-spectrum GBM data available from The...
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