Article

Population-based whole-genome sequencing with constrained gene analysis identifies predisposing germline variants in children with central nervous system tumors

2022-03-08

Abstract excerpt

<h4>Background</h4> The underlying cause of central nervous system (CNS) tumors in children is largely unknown. In this nationwide, prospective population-based study we investigate rare germline variants across known and putative CPS genes and genes exhibiting evolutionary intolerance of inactivating alterations in children with CNS tumors. <h4>Methods</h4> One hundred and twenty-eight children with CNS tumors un...

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Literature Corpus work: db2250e0-5347-550f-819e-d063cfa15c99
DOI: 10.1101/2022.03.01.22271578

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