Article
New insights into the genetics of glioblastoma multiforme by familial exome sequencing.
Oncotarget - 20 Mar 2015
Backes Christina, Harz Christian, Fischer Ulrike, Schmitt Jana, Ludwig Nicole, Petersen Britt-Sabina, Mueller Sabine C, Kim Yoo-Jin, Wolf Nadine M, Katus Hugo A, Meder Benjamin, Furtwängler Rhoikos, Franke Andre, Bohle Rainer, Henn Wolfram, Graf Norbert, Keller Andreas, Meese Eckart
Abstract excerpt
Glioblastoma multiforme (GBM) is the most aggressive and malignant subtype of human brain tumors. While a family clustering of GBM has long been acknowledged, relevant hereditary factors still remained elusive. Exome sequencing of families offers the option to discover respective genetic factors.We sequenced blood samples of one of the rare affected families: while both parents were healthy, both children were...
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