Article

Systematic identification of context-dependent gene-essentiality in Glioblastoma: The GBM-CoDE platform

2025-01-29

Abstract excerpt

Glioblastoma (GBM) is a heterogeneous and aggressive brain tumour that is invariably fatal despite maximal treatment. Genetic or transcriptomic ‘biomarkers’ could be used to stratify patients for treatments, however, pairing biomarkers with appropriate therapeutic ‘targets’ is challenging. Consequently, therapeutics have not yet been optimised for specific GBM patient subsets. Here we integrate genome-wide CRISPR/...

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Literature Corpus work: b7511ad9-1d62-5818-8e16-48c3812e0f33
DOI: 10.1101/2025.01.27.634260

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