Article

Using evolutionary constraint to define novel candidate driver genes in medulloblastoma

2022-11-03

Abstract excerpt

Current knowledge of cancer genomics is biased against non-coding mutations. Here, we use whole genome sequencing data from pediatric brain tumors, combined with evolutionary constraint inferred from 240 mammals to identify genes enriched in non-coding constraint mutations (NCCMs). We compare medulloblastoma (MB, malignant) to pilocytic astrocytoma (PA, benign) and find drastically different NCCM frequencies betwe...

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Literature Corpus work: bb997412-f70d-57fa-86d1-0bc596b061ba
DOI: 10.1101/2022.11.02.514465

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