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Mechanisms of nucleotide selection by telomerase

5 Jun 2020

Abstract excerpt

Telomerase extends telomere sequences at chromosomal ends to protect genomic DNA. During this process it must select the correct nucleotide from a pool of nucleotides with various sugars and base pairing properties, which is critically important for the proper capping of telomeric sequences by shelterin. Unfortunately, how telomerase selects correct nucleotides is unknown. Here, we determined structures of...

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PMID: 32501800
DOI: 10.7554/elife.55438

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